01 - In a small bowl, combine the salt, black pepper, paprika, garlic powder, and onion powder, mixing until evenly incorporated.
02 - Sprinkle both sides of each tilapia fillet evenly with the seasoning blend, pressing gently so the spices adhere to the surface.
03 - If using, lightly dredge each seasoned fillet in cornmeal or gluten-free flour, shaking off any excess to ensure a thin, even layer.
04 - Heat the olive oil or butter in a large nonstick skillet over medium-high heat until the fat shimmers and just begins to smoke lightly.
05 - Carefully lay the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3 to 4 minutes on the first side until a golden crust forms and the fish releases easily from the pan.
06 - Gently flip each fillet using a fish spatula and cook for another 2 to 3 minutes until the flesh is completely opaque and flakes easily when tested with a fork.
07 - Transfer the fillets to warm plates and serve immediately with fresh lemon wedges alongside for squeezing over the fish.