01 - Whisk buttermilk, salt, black pepper, garlic powder, and paprika in a large bowl. Add chicken breasts, turn to coat, cover, and refrigerate for at least 30 minutes up to 4 hours.
02 - Mix flour, panko breadcrumbs, paprika, cayenne pepper, oregano, salt, and black pepper in a shallow dish.
03 - Remove chicken from marinade letting excess drip off. Coat thoroughly in flour mixture, pressing gently to adhere.
04 - Heat vegetable oil in a large skillet over medium-high heat until shimmering.
05 - Fry chicken breasts for 5–6 minutes per side until golden brown and internal temperature reaches 165°F. Adjust heat to prevent burning.
06 - Transfer chicken to paper towel-lined plate to drain excess oil. Let rest for 5 minutes before serving.